Yangel Herrera recovered in time to feature for Granada at the weekend and he came off the bench to score against Atletico Madrid. Maxime Gonalons was also fit to play.
Granada have changed up their formation in recent weeks so Diego Martinez could spring a surprise here.
Kalidou Koulibaly and Faouzi Ghoulam both tested positive for COVID-19 at the start of the month and remain big doubts here.
Napoli look set to be without Diego Demme, Dries Mertens, Kostas Manolas and Elseid Hysaj again here.
With so many unavailable players, Napoli don't really have the options to shuffle their pack on Thursday. The biggest doubt is who starts in goal between David Ospina and Alex Meret.
Granada have only won one of their last seven matches and that was against lower league opposition. They coasted through their Europa League group but that was two months ago.
Napoli were prepared to sack Gennaro Gattuso at the weekend but the Serie A outfit ended up defeating Juventus 1-0. Now he needs to end their four-game losing streak on the road.
Neither side are in particularly good form heading into Thursday's first leg. Napoli should at least be on the up after defeating Juventus but it remains to be seen whether they can kick on from that result.
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