Wolfsberger boss Ferdinand Feldhofer is without duo Mario Leirgeb and Eliel Peretz for the welcome of Tottenham.
The former would usually have started and is set to be replaced by youngster Kai Stratznig in the middle of the park.
Feldhofer used a three-man defence at the weekend, but could revert to a 4-1-3-2 system he predominantly used in the group stages.
Giovani Lo Celso is Tottenham's only confirmed injury absentee for the trip to Austria, while Jose Mourinho elected not to include Joe Rodon in the club's Europa League squad for the knockout stages.
Starting full-backs Serge Aurier and Sergio Reguilon may both return for Spurs, though Mourinho could keep them both fresh for Sunday's meeting with West Ham.
While desperate to get back to winning ways, the Spurs is set to keep faith with his usual Europa League personnel, which would see Carlos Vinicius, Gareth Bale and Lucas Moura all start.
Dele Alli is in line to make his first competitive start since the 5-0 FA Cup win at Marine last month.
Wolfsberger secured their third win in seven against Admira Moedling at the weekend, which was the ideal morale boost ahead of the welcome of Tottenham. The Austrian side have lost just one of their last eight home matches.
Tottenham need to shake themselves out of their current funk with head coach Jose Mourinho overseeing a run of five defeats in six. Three successive away defeats doesn't make for great reading as Spurs seek to secure a place in the last-16 of the competition.
Both sides will be confident of scoring, but it's Spurs who may be the happier of the two teams come full time on Thursday night.
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